Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease
نویسندگان
چکیده
منابع مشابه
Chronic Granulomatous Disease, Case Report and Review of Literature
Chronic granulomatous disease (CGD) is a rare inherited disorder characterized by inability of phagocytes to generate oxygen radicals needed for intracellular killing of phagocytic microorganisms. We report a 2.5-year-old Iranian female with multiple liver abscesses. She was admitted in surgical ward because of abdominal pain and fever for one month duration that had no response to conventio...
متن کاملMolecular basis of chronic granulomatous disease.
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متن کاملChronic granulomatous disease: recent advances in pathophysiology and treatment.
Chronic granulomatous disease (CGD) was characterised half a century ago as a primary immunodeficiency disorder of phagocytic cells resulting in failure to kill a specific spectrum of bacteria and fungi and in concomitant hyperinflammation with widespread tissue granuloma formation. CGD now comprises five genetic defects, each impairing one of five essential subunits of the phagocyte NADPH oxid...
متن کاملrecessive chronic granulomatous disease
A 2 year old girl presented with epilepsy 16 months after being diagnosed as having autosomal recessive chronic granulomatous disease. Computed tomography showed a cerebral mass which was surgicaily removed and proved histologicaily to be an aspergilloma. This case illustrates the application of molecular diagnostic techniques to the diagnosis of chronic granulomatous disease. The occurrence of...
متن کاملChronic Granulomatous Disease
Background: Chronic granulomatous disease (CGD) is an uncommon primary immunodeficiency that can be inherited in an X-linked (XL) or an autosomal recessive (AR) manner. We reviewed our large, single-center US experience with CGD. Methods: We reviewed 27 patients at Ann & Robert H. Lurie Children's Hospital of Chicago from March 1985 to November 2013. Fisher exact test was used to compare differ...
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ژورنال
عنوان ژورنال: Journal of the Pediatric Infectious Diseases Society
سال: 2018
ISSN: 2048-7193,2048-7207
DOI: 10.1093/jpids/piy008